Yazar "Gülçin, İlhami" için listeleme
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Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Demir, Yeliz; Taslimi, Parham; Özaslan, Muhammet Serhat; Öztaşkın, Necla; Çetinkaya, Yasin; Gülçin, İlhami; Göksu, Süleyman (Wiley-V C H Verlag GMBH, 2018)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds
Huyut, Zubeyir; Beydemir, Şükrü; Gülçin, İlhami (Hindawi LTD, 2017)Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, alpha-amylase and alpha-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Öztaşkın, Necla; Maras, Ahmet; Gülçin, İlhami; Göksu, Süleyman (Elsevier Science BV, 2018)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
Taslimi, Parham; Osmanova, Sabiya; Gülçin, İlhami; Sardarova, Sabira; Farzaliyev, Vagif; Sujayev, Afsun; Kufrevioğlu, Ömer İrfan (Wiley, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes
Huyut, Zubeyir; Beydemir, Şükrü; Gülçin, İlhami (Wiley, 2017)Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of ... -
Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients
Işık, Mesut; Beydemir, Şükrü; Yılmaz, Aslan; Naldan, Muhammet Emin; Aslan, Hatice Esra; Gülçin, İlhami (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)Background: Pathogenesis of ischemic brain injury is occurred by crucial metabolic reasons. For instance, oxidative stress from free radical generation is causing to the thrombotic cerebrovascular stroke. In this case, the ... -
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
Demir, Yeliz; Işık, Mesut; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2017)Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ... -
Synthesis and bioactivity of several new hetaryl sulfonamides
Taslimi, Parham; Sujayev, Afsun; Mamedova, Sevgi; Kalin, Pınar; Gülçin, İlhami; Sadeghian, Nastaran; Mamedov, Sabir (Taylor & Francis LTD, 2017)1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and ... -
Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
Gülçin, İlhami; Abbasova, Malahat; Taslimi, Parham; Huyut, Zubeyir; Safarova, Leyla; Sujayev, Afsun; Supuran, Claudiu T. (Taylor & Francis LTD, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. Therefore, the reactions of aminomethylation and alkoxymethylation of ... -
Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors
Tugrak, Mehtap; Gül, Halise İnci; Bandow, Kenjiro; Sakagami, Hiroshi; Gülçin, İlhami; Özkay, Yusuf; Supuran, Claudiu T. (Academic Press Inc Elsevier Science, 2019)New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects ...